A link between Celebrex and heart valve calcification

A Big-Data analysis of patient records at Vanderbilt University has found a link specifically between Celebrex and heart valve calcification. A team of researchers started out by testing celecoxib, the active compound in Celebrex, on valve cells in an effort to see if it could double as an aortic stenosis therapy. It made the problem worse. To confirm their theory about a link between celecoxib and valve calcification, the researchers analyzed more than 8,600 relevant, anonymous patient records from Vanderbilt University Medical Center. They checked whether there was a link between Celebrex use and aortic valve disease, and, after correcting for other risk factors, discovered that patients who had taken Celebrex had a 35 percent increased prevalence of valve disease.

Provided by Vanderbilt University

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